When the pandemic started my partner Cory and I were in Florida with my family in a relatively isolated house. We knew we were returning to Boston to a lockdown and my parents knew they were returning to Pennsylvania to a lockdown. When we flew back we were given wipes to wipe down our seats and paper placemats came with the in-flight snacks, which like many of the things we did seem bizarre and futile in retrospect. Masks were as yet not a thing in the United States.
I was going stir-crazy in lockdown and signed myself and Cory up for every vaccine trial registry I could find. My main project at work was shut down and after I passed my qualifying exam over zoom I was stuck at home reading news articles and wanting to contribute something, anything to society, to the fight against covid specifically. I also wanted me and Cory to get vaccinated as soon as possible.
I was contacted about two trials: the first I was not high risk enough to qualify for; the second, the trial for the Novavax vaccine, we qualified for by virtue of living in a large apartment building with a shared stairwell and fluid airflow between apartments. I was also doing the grocery shopping at that point, which meant pre-organizing the shopping list by aisle and speed-running Market Basket at $10/minute. This was when Market Basket had a long line outside for density control and we were driving our first car, a 2001 Highlander that felt illegal to drive and indeed failed its next inspection.
Unlike the other covid vaccines, the Novavax vaccine is protein-based, which means it can live in the fridge. The vaccine includes a modified spike protein and an adjuvant. The spike protein is made using moth cells. The adjuvant is from soapbark tree extract. That the vaccine is protein-based makes it easier to transport and, I think, more palatable to people who are vaccine-hesitant.
At that point, Phase 1 and 2 results were already published. I felt comfortable enough with the results to enroll in Phase 3. I was study member 17 at the Boston study site.
These changed a bit as the study went on, but the initial planned study visits were:
- a pre-screening phone call
- a virtual screen (informed consent over zoom)
- an in-person vaccination/placebo visit (3-4 hours)
- a second vaccination visit 21 days later
- both shots again
- a check-in at 3 months
- 6 months
- 12 months
- 18 months
- and 24 months
The study was double-blind: everyone got four shots, with either the first two (2/3rds chance) or the last two (1/3rd chance) being the real vaccine and the other two being placebo (saline). This was my first experience with the placebo effect in my own body: when I got shots 1 and 2 I was convinced they were the real deal, but after shot 4 I am quite confident that shots 3 and 4 were the vaccine and shots 1 and 2 were placebo.
The study also involved substantial self-reporting. We kept a diary in an app on our phones where we reported our temperature (measured with a provided thermometer) and presence or absence of a list of potential symptoms. If we had a fever of at least 100 degrees or symptoms for two days in a row, the app triggered reporting of additional symptoms and blood oxygen levels, we self-administered and refrigerated provided nose swabs for three days, and we reported to the study site in person for a check-up, an interview, and additional nose swabs.

As part of Operation Warp Speed, we got paid a lot of money for being in this trial compared to non-covid vaccine trials. We got paid for every shot, we got paid for routine check-ins and blood draws, and we got paid to come in when we got sick. The money was deposited on a debit card. We also got snacks at every visit.

Shot 1: Placebo (probably)
January 21st, 2021.
When we got home we were completely wiped out. We both fell asleep on the couch in the living room, me flopped on top of Cory, both of us in very uncomfortable positions.
My arm hurt for three days. I had fatigue, malaise, and a headache for two days and joint pain for three days. The placebo effect was so strong, I assumed at the time that I had gotten the real shot. Maybe the effect was from being injected with saline. Maybe the effect was from the disruption to my routine. Maybe the effect was from expecting an effect.

Shortly after my first shot, extremely promising Phase 3 results were reported from the UK and South Africa.
Shot 2: More placebo (probably)
February 11th, 2021.
Fatigue for four days, malaise for a day, muscle pain and joint pain for two days.


Shot 3: The real deal, first dose
April 27th, 2021.
Diarrhea the day after the shot, probably not from the shot but who knows.

Here are the day’s snacks:


Here’s the study check-in area and the room where I hung out during the visit:


Here is my blood draw:


Finally, here are the buttons to the elevator, which we quite liked. The down button is the top button. The bottom button, which should be the down button, is the button for medical emergencies.

Shot 4: The second dose
May 18th, 2021.
Here is when I determined that shots 3 and 4 were probably the real deal and shots 1 and 2 were probably placebo. Fever, shortness of breath, headache, muscle aches, and fatigue for two days.

Here are my snacks and my temporary vax card:


This vax card was soon replaced with a more legitimate-looking, cardstock vax card that as you can tell for a long time lived folded up in my phone wallet:

After the initial vaccine trial we had the option of sticking around for the booster trial. This one was not double-blind: everyone got one shot, and that one shot was the real deal.
Shot 5: The booster
January 18th, 2022.
Pain in my arm for three days, tenderness for four days, and redness for two days. Fatigue for five days, malaise for three days, muscle and joint pain for four days, and headache for two days.

The study ended and was published. If you look closely, you can find me as a data point in the Phase 3 publication: “Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine.” Today, I’m in a (unpaid) biorepository study as a special and rare Novavax-only datapoint.
The vaccine got Emergency Use Authorization in August 2022. You can look up locations where the Novavax vaccine is offered here.
Being in the Novavax trial was probably the most meaningful thing I did during the pandemic, especially early in the pandemic, and possibly one of the most impactful things I will end up doing in my lifetime. It gave me purpose at a time when I felt like the news was happening to me and there was nothing I could do about it, and there was nothing I could do to stop myself and my loved ones and the city around me from being washed into the course of history. It is very special to me that I got to be a part of getting a vaccine out into the world.
I hope someday I’ll be chosen for another vaccine study. Because would I do it again? Without question.






























